- Natural product: Green tea (Camellia sinensis)
- Associated study: Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes
In Vitro Enzyme Inhibition Experiment
Inhibition of CYP2C19 by (-)-Epigallocatechin Gallate in HLM (IC50 Determination)
Inhibition was detected. Cutoff used — IC50 determination
- CYP2C19 4311137
Cell fraction Pooled human liver microsomes -7999662
Results
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
0.2 mg/mL
Commercially available
100 µL
40 min
NADPH
Not available
Not available
29 µM
1-218 µM