Inhibition of Speciociliatine for CYP2C19 CSV JSON

In Vitro Enzyme Inhibition Experiment

Inhibition of Speciociliatine for CYP2C19

Inhibition was detected.  Cutoff used —

IC50 = 45 μM

mephenytoin, (s)-

speciociliatine

4-hydroxymephenytoin, (s)-

  • CYP2C19 4311137

Cell fraction Pooled human liver microsomes -7999662

Results

% result estimated from Figure S3 at around 100 µM

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

0.1 mg/ml

200 µL

60 min

NADPH

40 µM

0 - 100 µM

Control Experiment