Licorice (Glycyrrhiza inflata)

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Latin Binomial: Glycyrrhiza inflata
Common Names: Licorice and Zhangguogancao

Natural Product Information From GSRS

Resource Identifier
= Induction
= Inhibition
= No overall effect

Published in vitro enzyme experiments

ethanolic extract of licorice g. inflata
CYP1A2
CYP2A6
CYP2B6
CYP2C8
CYP2C9
CYP2C19
CYP2D6
CYP3A4
CYP2E1

Chemical characterization

liquiritin glycyrrhizin isoliquiritigenin isoliquiritin licuraside liquiritin apioside glycyrrhetinic acid isoliquiritin apioside licochalcone a glycycoumarin p-hydroxy-benzylmalonic acid (hbma) liquiritigenin
Chemical characterization of Licorice, Glycyrrhiza inflata 1.33 ± 0 % 1.42 ± 0 % 0.15 ± 0 % 0.18 ± 0 % 0.17 ± 0 % 7.7 ± 0 % 0.2 ± 0 % 1.99 ± 0 % 5.24 ± 0 % 0.005 ± 0 % 5.06 ± 0 % 0.26 ± 0 %
ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-x89xLA Licorice (Glycyrrhiza inflata) Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents Inhibition of CYP1A2 by G. inflata Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
phenacetin acetaminophen ethanolic extract of licorice g. inflata
NPDI-13n6-Q Licorice (Glycyrrhiza inflata) Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents Negligible inhibition of CYP2A6 by G. inflata Licorice extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2A6
coumarin 7-hydroxycoumarin ethanolic extract of licorice g. inflata
NPDI-mWgNew Licorice (Glycyrrhiza inflata) Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents Inhibition of CYP2B6 by G. inflata Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2B6
bupropion hydroxybupropion ethanolic extract of licorice g. inflata
NPDI-SUW3zQ Licorice (Glycyrrhiza inflata) Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents Inhibition of CYP2C8 by G. inflata Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine ethanolic extract of licorice g. inflata
NPDI-Y7VPTg Licorice (Glycyrrhiza inflata) Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents Inhibition of CYP2C9 by G. inflata Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
tolbutamide hydroxymethyltolbutamide ethanolic extract of licorice g. inflata
NPDI-hR5T0g Licorice (Glycyrrhiza inflata) Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents Inhibition of CYP2C19 by G. inflata Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- ethanolic extract of licorice g. inflata
NPDI-1PLoEQ Licorice (Glycyrrhiza inflata) Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents Inhibition of CYP2D6 by G. inflata Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan ethanolic extract of licorice g. inflata
NPDI-pHgnHQ Licorice (Glycyrrhiza inflata) Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents Inhibition of CYP3A4 by G. inflata Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam ethanolic extract of licorice g. inflata
NPDI-beIHRg Licorice (Glycyrrhiza inflata) Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents Inhibition of CYP3A4 by G. inflata Licorice extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
testosterone 6beta-hydroxytestosterone ethanolic extract of licorice g. inflata
NPDI-eDM7DQ Licorice (Glycyrrhiza inflata) Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents Negligible inhibition of CYP2E1 by G. inflata Licorice extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2E1
chloroxazone 6-hydroxychloroxazone ethanolic extract of licorice g. inflata
NPDI-l1_dTA Licorice (Glycyrrhiza inflata) Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents Chemical characterization of Licorice, Glycyrrhiza inflata Characterization of Material