- Natural product: Licorice (Glycyrrhiza inflata)
- Associated study: Cytochrome P450 inhibition by licorice species Glycyrrhiza inflata and fourteen licorice constituents
In Vitro Enzyme Inhibition Experiment
Inhibition of CYP3A4 by G. inflata Licorice extract
Inhibition was detected. Cutoff used —
> 100 µg/mL
- CYP3A4 4306811
Cell fraction Pooled human liver microsomes -7999662
Results
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
0.2 mg/mL
10 min
NADPH
2.5 µM
11 concentrations from 0.005–250 μg/mL