Green tea (Camellia sinensis)

Full Name: Camellia sinensis (L.) Kuntze
Kingdom: Plantae
Order: Ericales
Family Name: Theaceae
Latin Binomial: Camellia sinensis
Common Names: Black tea, Green tea, Oolong tea, Tea and White Tea

Natural Product Information From GSRS

Resource Identifier
= Induction
= Inhibition
= No overall effect

Published in vitro enzyme experiments

green tea leaf extract (-)-gallocatechin (-)-epigallocatechin gallate epicatechin gallate catechin (-)-epicatechin nicardipine epigallocatechin epigallocatechin gallate green tea leaf (-)-epigallocatechin
UGT1A10
UGT1A8
UGT1A1
UGT
CYP1A2
CYP3A4
CYP2E1
SULT1A3
CYP2C9
CYP1A1
SULT1A1
UGT1A6
UGT1A9
CYP2A6
CYP2B6
CYP2D6
CYP2C8
CYP2C19
UGT1A4

Published in vitro transporter experiments

green tea leaf (-)-epigallocatechin gallate
P-gp (ABCB1)
MATE1 (SLC47A1)
OCT1 (SLC22A1)
OCT2 (SLC22A2)
OATP1B3 (SLCO1B3)
OATP1B1 (SLCO1B1)
MATE2-K (SLC47A2)
OATP1A2 (SLCO1A2)

Chemical characterization

(-)-epigallocatechin gallate (-)-epicatechin (-)-epigallocatechin (-)-epicatechin-3-gallate catechin gallocatechin
Green Tea Characterization of Material Experiment 14.61 ± 0.34 mg/g sample 3.366 ± 0.066 mg/g sample 13.55 ± 0.23 mg/g sample 8.43 ± 0.18 mg/g sample 0.171 ± 0.013 mg/g sample 1.201 ± 0.094 mg/g sample

Published clinical experiments

Inhibition detected
buspirone, nadolol
No overall effect
alprazolam, caffeine, dextromethorphan, dextromethorphan, losartan




Data points represent the following samples (click to show/hide):

ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-wur44g Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein P-gp mediated digoxin transport in Caco-2 cells In Vitro Transporter Kinetics (Control experiment) positive — In Vitro Transport
  • P-gp (ABCB1)
 digoxin
NPDI-aqYl1g Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by Green Tea Leaf Extract (T21) (Ki determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 4'-glucuronide green tea leaf extract
NPDI-PRsP6g Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of P-gp by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
 digoxin green tea leaf
NPDI-p3x0vg Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT by (-)-Gallocatechin (Screening) In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • UGT
4-methylumbelliferone 4-methylumbelliferone glucuronide (-)-gallocatechin
NPDI-jljbXg Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1 and 1A8 by Green Tea Leaf Extract (T21) (Ki determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A8
raloxifene raloxifene 6-glucuronide green tea leaf extract
NPDI-6qDdNA Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of P-gp by (-)epigallocatecin gallate In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • P-gp (ABCB1)
 digoxin (-)-epigallocatechin gallate
NPDI--cZmFQ Green tea (Camellia sinensis) Green Tea Metabolomics Green Tea Metabolomics Experiment Metabolomics
NPDI-XIaDNg Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epigallocatechin Gallate (Ki determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 4'-glucuronide (-)-epigallocatechin gallate
NPDI-WIQ_6A Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epicatechin Gallate (Ki determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 6-glucuronide epicatechin gallate
NPDI-1nd-Ow Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epicatechin Gallate (Ki determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 4'-glucuronide epicatechin gallate
NPDI-8CdNjg Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epigallocatechin Gallate (Ki determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 6-glucuronide (-)-epigallocatechin gallate
NPDI-qkiI-g Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation In Vitro Enzyme Inhibition (Control experiment) positive — In Vitro Enzyme Inhibition
  • UGT
4-methylumbelliferone 4-methylumbelliferone glucuronide green tea leaf extract
NPDI-ubCatg Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by (+)-catechin (Screening) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 6-glucuronide catechin
NPDI-AXdpJA Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT by (-)-Epicatechin Gallate (IC50 determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT
4-methylumbelliferone 4-methylumbelliferone glucuronide epicatechin gallate
NPDI-y3-V_w Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT
4-methylumbelliferone 4-methylumbelliferone glucuronide green tea leaf extract
NPDI-TIvDHw Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by (+)-catechin (Screening) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 4'-glucuronide catechin
NPDI-VlvwrQ Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epicatechin (Screening) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 6-glucuronide (-)-epicatechin
NPDI-wl1otQ Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epicatechin (Screening) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 4'-glucuronide (-)-epicatechin
NPDI-WhE0iA Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epicatechin Gallate (Screening) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 4'-glucuronide epicatechin gallate
NPDI-rX0CIg Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epigallocatechin Gallate (Screening) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 6-glucuronide (-)-epigallocatechin gallate
NPDI-uGwaFA Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A10, and 1A8 by (-)-Epigallocatechin Gallate (Screening) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 4'-glucuronide (-)-epigallocatechin gallate
NPDI--hYNlQ Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by Nicardipine (Positive Control; Screening) In Vitro Enzyme Inhibition (Control experiment) positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 4'-glucuronide nicardipine
NPDI-yWS4NQ Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1 and 1A8 by Nicardipine (Positive Control; Screening) In Vitro Enzyme Inhibition (Control experiment) positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A8
raloxifene raloxifene 6-glucuronide nicardipine
NPDI-7pd4sA Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT by (-)-Epigallocatechin (Screening) In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • UGT
4-methylumbelliferone 4-methylumbelliferone glucuronide epigallocatechin
NPDI-7el55g Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT by (-)-Epigallocatechin Gallate (IC50 Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT
4-methylumbelliferone 4-methylumbelliferone glucuronide (-)-epigallocatechin gallate
NPDI-cpRc8Q Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of MATE1 by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • MATE1 (SLC47A1)
 metformin green tea leaf
NPDI-CWM_sQ Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT by (-)-Epicatechin Gallate (Screening) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT
4-methylumbelliferone 4-methylumbelliferone glucuronide epicatechin gallate
NPDI-N39uaQ Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT by Nicardipine in HIM (Screening) In Vitro Enzyme Inhibition (Control experiment) positive — In Vitro Enzyme Inhibition
  • UGT
4-methylumbelliferone 4-methylumbelliferone glucuronide nicardipine
NPDI-cTDX2A Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT by (-)-Epicatechin (Screening) In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • UGT
4-methylumbelliferone 4-methylumbelliferone glucuronide (-)-epicatechin
NPDI-Hzxkxw Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epicatechin Gallate (Screening) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 6-glucuronide epicatechin gallate
NPDI-ArhlIA Green tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 Percent inhibition of CYP1A2 by epicatechin gallate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
7-ethoxyresorufin resorufin epicatechin gallate
NPDI-JGDRVA Green tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 Percent inhibition of CYP3A4 by epicatechin gallate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam epicatechin gallate
NPDI-Cuu5WA Green tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam epigallocatechin gallate
NPDI-_5Ix4Q Green tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2E1
4-nitrophenol 4-nitrocatechol epigallocatechin gallate
NPDI-QJ8BsA Green tea (Camellia sinensis) Pharmacokinetics and Safety of Green Tea Polyphenols after Multiple-Dose Administration of Epigallocatechin Gallate and Polyphenon E in Healthy Individuals PK and safety after multiple-dose administration of epigallocatechin gallate (EGCG) 800 mg In Vivo Pharmacokinetics
NPDI-p7eJTA Green tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
7-ethoxyresorufin resorufin epigallocatechin gallate
NPDI-L5RmbA Green tea (Camellia sinensis) Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3 green tea inhibition of SULT1A3 using ritodrine as the substrate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • SULT1A3
ritodrine ritodrine sulfate ester green tea leaf
NPDI-4v_54A Green tea (Camellia sinensis) Effects of repeated green tea catechin administration on human cytochrome P450 activity. In Vivo Interaction negative — No Effect (based on bioequivalence limits)
  • CYP1A2
caffeine green tea leaf
NPDI-IkNjmw Green tea (Camellia sinensis) Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. In vivo PK of tea polyphenols 800 mg Polyphenon E capsules In Vivo Pharmacokinetics
NPDI-8cPLyw Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OCT1 by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OCT1 (SLC22A1)
 metformin green tea leaf
NPDI-iisBhQ Green tea (Camellia sinensis) Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. In vivo PK of tea polyphenols 800 mg EGCG capsules In Vivo Pharmacokinetics
NPDI-EVjSRA Green tea (Camellia sinensis) Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. In vivo PK of tea polyphenols 200 mg Polyphenon E capsules In Vivo Pharmacokinetics
NPDI-_7AWMw Green tea (Camellia sinensis) Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. In vivo PK of tea polyphenols 400 mg Polyphenon E capsules In Vivo Pharmacokinetics
NPDI-nm2fYg Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OCT2 by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OCT2 (SLC22A2)
 metformin green tea leaf
NPDI-UhMAjQ Green tea (Camellia sinensis) Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. In vivo PK of tea polyphenols 400 mg EGCG capsules In Vivo Pharmacokinetics
NPDI-aYDjxA Green tea (Camellia sinensis) Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. In vivo PK of tea polyphenols 600 mg EGCG capsules In Vivo Pharmacokinetics
NPDI-kZAc2A Green tea (Camellia sinensis) Blood and Urine Levels of Tea Catechins after Ingestion of Different Amounts of Green Tea by Human Volunteers Blood and urine levels of tea catechins after 4.5 g green tea extract administration In Vivo Pharmacokinetics
NPDI-FBHH1Q Green tea (Camellia sinensis) Effects of repeated green tea catechin administration on human cytochrome P450 activity. In Vivo Interaction negative — No Effect (based on bioequivalence limits)
  • CYP2D6
dextromethorphan green tea leaf
NPDI-i6A3tw Green tea (Camellia sinensis) Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. Green tea interaction with nadolol In Vivo Interaction positive — PK Interaction - Increased systemic exposure
  • OATP1A2 (SLCO1A2)
 nadolol green tea leaf
NPDI-F2VDuA Green tea (Camellia sinensis) Blood and Urine Levels of Tea Catechins after Ingestion of Different Amounts of Green Tea by Human Volunteers Blood and urine levels of tea catechins after 3.0 g green tea extract administration In Vivo Pharmacokinetics
NPDI-ZpUpLQ Green tea (Camellia sinensis) Blood and Urine Levels of Tea Catechins after Ingestion of Different Amounts of Green Tea by Human Volunteers Blood and urine levels of tea catechins after 1.5 g green tea extract administration In Vivo Pharmacokinetics
NPDI-MopEIQ Green tea (Camellia sinensis) Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. In vivo PK of tea polyphenols 600 mg Polyphenon E capsules In Vivo Pharmacokinetics
NPDI-_MbFQg Green tea (Camellia sinensis) Green tea (Camellia sinensis) extract does not alter cytochrome P450 3A4 or 2D6 activity in healthy volunteers. In vivo NPDI experiment In Vivo Interaction negative — No Effect (based on bioequivalence limits)
  • CYP3A4
alprazolam green tea leaf extract
NPDI-cY8J6A Green tea (Camellia sinensis) Green tea (Camellia sinensis) extract does not alter cytochrome P450 3A4 or 2D6 activity in healthy volunteers. CYP2D6 inhibition experiment In Vivo Interaction negative — No Effect (based on bioequivalence limits)
  • CYP2D6
dextromethorphan green tea leaf extract
NPDI-fXRM8w Green tea (Camellia sinensis) Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. In vivo PK of tea polyphenols 200 mg EGCG capsules In Vivo Pharmacokinetics
NPDI-cNMCFg Green tea (Camellia sinensis) Plasma pharmacokinetics of catechin metabolite 4'-O-Me-EGC in healthy humans Pharmacokinetics after Single Dose of Green Tea In Vivo Pharmacokinetics
NPDI-m23CAQ Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epigallocatechin (Screening) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 6-glucuronide (-)-epigallocatechin
NPDI-SSGtgQ Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OATP1B3 by (-)-epigallocatechin gallate In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • OATP1B3 (SLCO1B3)
 atorvastatin (-)-epigallocatechin gallate
NPDI-Xe-X8A Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epigallocatechin (Screening) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 4'-glucuronide (-)-epigallocatechin
NPDI-sKz_0w Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OATP1B3 by (-)-epigallocatechin gallate In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OATP1B3 (SLCO1B3)
 bromosulfophthalein (-)-epigallocatechin gallate
NPDI-8SDYnQ Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OATP1B1 by (-)-epigallocatechin gallate In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OATP1B1 (SLCO1B1)
 atorvastatin (-)-epigallocatechin gallate
NPDI-OBEe_w Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OATP1B3 by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OATP1B3 (SLCO1B3)
 atorvastatin green tea leaf
NPDI-Iy3POQ Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OATP1B1 by (-)-epigallocatechin gallate In Vitro Transporter Inhibition negative — In Vitro Transporter Non-inhibition
  • OATP1B1 (SLCO1B1)
 bromosulfophthalein (-)-epigallocatechin gallate
NPDI-KsBTjg Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OATP1B1 by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OATP1B1 (SLCO1B1)
 atorvastatin green tea leaf
NPDI-VWdSJg Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OATP1B1 by Green Tea Leaf In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OATP1B1 (SLCO1B1)
 bromosulfophthalein green tea leaf
NPDI-wmFE6g Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OATP1B3 by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OATP1B3 (SLCO1B3)
 bromosulfophthalein green tea leaf
NPDI-Iu375A Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Atorvastatin uptake in OATP1B3 cells In Vitro Transporter Kinetics (Control experiment) positive — In Vitro Transport
  • OATP1B3 (SLCO1B3)
 atorvastatin
NPDI-98YFOA Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Bromosulfophthalein uptake in OATP1B1 cells In Vitro Transporter Kinetics (Control experiment) positive — In Vitro Transport
  • OATP1B1 (SLCO1B1)
 bromosulfophthalein
NPDI-vOa6TA Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Bromosulfophthalein uptake in OATP1B3 cells In Vitro Transporter Kinetics (Control experiment) positive — In Vitro Transport
  • OATP1B3 (SLCO1B3)
 bromosulfophthalein
NPDI-GaLUxw Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of MATE1 by (-)-epigallocatechingallate In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • MATE1 (SLC47A1)
 metformin (-)-epigallocatechin gallate
NPDI-DGEDfw Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of MATE2-K by (-)-epigallocatechingallate In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • MATE2-K (SLC47A2)
 metformin (-)-epigallocatechin gallate
NPDI-D84qNg Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Atorvastatin uptake in OATP1B1 cells In Vitro Transporter Kinetics (Control experiment) positive — In Vitro Transport
  • OATP1B1 (SLCO1B1)
 atorvastatin
NPDI-b-Qyxw Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Metformin uptake in OCT2 cells In Vitro Transporter Kinetics (Control experiment) positive — In Vitro Transport
  • OCT2 (SLC22A2)
 metformin
NPDI-27Q7-A Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OCT1 by (-)-epigallocatechin gallate In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OCT1 (SLC22A1)
 metformin (-)-epigallocatechin gallate
NPDI-bVuJYQ Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of OCT2 by (-)-epigallocatechin gallate In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OCT2 (SLC22A2)
 metformin (-)-epigallocatechin gallate
NPDI-eejWAQ Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Metformin uptake in MATE1 cells In Vitro Transporter Kinetics (Control experiment) positive — In Vitro Transport
  • MATE1 (SLC47A1)
 metformin
NPDI-WsMb-g Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Metformin uptake in MATE2-K cells In Vitro Transporter Kinetics (Control experiment) positive — In Vitro Transport
  • MATE2-K (SLC47A2)
 metformin
NPDI-F3BK2A Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Metformin uptake in OCT1 cells In Vitro Transporter Kinetics (Control experiment) positive — In Vitro Transport
  • OCT1 (SLC22A1)
 metformin
NPDI-2KGgbg Green tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 Percent inhibition of CYP2C9 by epicatechin gallate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac epicatechin gallate
NPDI-pD4STA Green tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 Percent inhibition of CYP1A1 by (-)-epicatechin In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP1A1
7-ethoxycoumarin coumarin (-)-epicatechin
NPDI-GdcFMg Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Inhibition of MATE2-K by Green Tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • MATE2-K (SLC47A2)
 metformin green tea leaf
NPDI-vyz23w Green tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxycoumarin coumarin epigallocatechin gallate
NPDI-38xlLg Green tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac epigallocatechin gallate
NPDI-X_yVFw Green tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 Percent inhibition of CYP1A1 by epicatechin gallate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxycoumarin coumarin epicatechin gallate
NPDI-xsuAIg Green tea (Camellia sinensis) Effects of repeated green tea catechin administration on human cytochrome P450 activity. In Vivo Interaction positive — PK Interaction - Increased systemic exposure
  • CYP3A4
buspirone green tea leaf
NPDI-H8eoWA Green tea (Camellia sinensis) Effects of repeated green tea catechin administration on human cytochrome P450 activity. In Vivo Interaction negative — No Effect (based on bioequivalence limits)
  • CYP2C9
losartan green tea leaf
NPDI-wYUfKA Green tea (Camellia sinensis) Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. OATP1A2 in vitro inhibition In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OATP1A2 (SLCO1A2)
 nadolol (-)-epigallocatechin gallate
NPDI-lih1tg Green tea (Camellia sinensis) Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects. OATP1A2 inhibition with green tea In Vitro Transporter Inhibition positive — In Vitro Transporter Inhibition
  • OATP1A2 (SLCO1A2)
 nadolol green tea leaf
NPDI-OQFZmw Green tea (Camellia sinensis) Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3 green tea inhibition of SULT1A1 using ritodrine as the substrate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • SULT1A1
ritodrine ritodrine sulfate ester green tea leaf
NPDI-Dg01cQ Green tea (Camellia sinensis) Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities Inhibition of UGT1A6 by Epigallocatechin Gallate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A6
serotonin serotonin glucuronide epigallocatechin gallate
NPDI-mzhpNw Green tea (Camellia sinensis) Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities Inhibition of UGT1A9 by Epigallocatechin Gallate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A9
mycophenolic acid mycophenolic acid 7-o-glucuronide epigallocatechin gallate
NPDI-q6-gZQ Green tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2A6
coumarin 7-hydroxycoumarin epigallocatechin gallate
NPDI-4i54tA Green tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 Percent inhibition of CYP2E1 by epicatechin gallate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2E1
4-nitrophenol 4-nitrocatechol epicatechin gallate
NPDI-CPfQsA Green tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 Percent inhibition of CYP2A6 by epicatechin gallate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2A6
coumarin 7-hydroxycoumarin epicatechin gallate
NPDI-LZlNyQ Green tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP3A by (-)-Epigallocatechin Gallate in HLM (Ki Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam (-)-epigallocatechin gallate
NPDI-6x_uKQ Green tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP3A by (-)-Epigallocatechin Gallate in HLM (IC50 Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam (-)-epigallocatechin gallate
NPDI-AIlkaw Green tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP3A by (-)-Epigallocatechin Gallate in HIM (Ki Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam (-)-epigallocatechin gallate
NPDI-FMvj7w Green tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP3A by (-)-Epigallocatechin Gallate in HIM (IC50 Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam (-)-epigallocatechin gallate
NPDI-KMW0mA Green tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP2B6 by (-)-Epigallocatechin Gallate in HLM (IC50 Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2B6
bupropion hydroxybupropion (-)-epigallocatechin gallate
NPDI-kN7saQ Green tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP2D6 by (-)-Epigallocatechin Gallate in HLM (Ki Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan (-)-epigallocatechin gallate
NPDI-P8wXLQ Green tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP2D6 by (-)-Epigallocatechin Gallate in HLM (IC50 Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan (-)-epigallocatechin gallate
NPDI-Hh_vaQ Green tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP2C8 by (-)-Epigallocatechin Gallate in HLM (IC50 Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine (-)-epigallocatechin gallate
NPDI-oFLPrw Green tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP2B6 by (-)-Epigallocatechin Gallate in HLM (Ki Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2B6
bupropion hydroxybupropion (-)-epigallocatechin gallate
NPDI-YR9AgQ Green tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP2C19 by (-)-Epigallocatechin Gallate in HLM (Ki Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- (-)-epigallocatechin gallate
NPDI-cXHH7g Green tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP2C19 by (-)-Epigallocatechin Gallate in HLM (IC50 Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C19
mephenytoin, (s)- 4-hydroxymephenytoin, (s)- (-)-epigallocatechin gallate
NPDI-rnQE5Q Green tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes Inhibition of CYP2C8 by (-)-Epigallocatechin Gallate in HLM (Ki Determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C8
amodiaquine n-desethylamodiaquine (-)-epigallocatechin gallate
NPDI-URZBxQ Green tea (Camellia sinensis) Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities Inhibition of UGT1A4 by Epigallocatechin Gallate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A4
trifluoperazine trifluoperazine glucuronide epigallocatechin gallate
NPDI-mLlCzw Green tea (Camellia sinensis) Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3 Green tea inhibition of SULT1A1 using 4-nitrophenyl as the substrate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • SULT1A1
p-nitrophenol 4-nitrophenyl sulfate green tea leaf
NPDI-_Zkjzg Green tea (Camellia sinensis) Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3 Green tea inhibition of SULT1A3 using dopamine as the substrate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • SULT1A3
dopamine dopamine sulfate green tea leaf
NPDI-r41Z9w Green tea (Camellia sinensis) Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity. EGCG inhibition of UGT1A1 In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
17-beta-estradiol 17-beta-estradiol-3-o-glucuronide epigallocatechin gallate
NPDI-EczRtA Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT by (-)-Epigallocatechin Gallate (Screening) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT
4-methylumbelliferone 4-methylumbelliferone glucuronide (-)-epigallocatechin gallate
NPDI-PsGh1w Green tea (Camellia sinensis) Green Tea Characterization of Material Green Tea Characterization of Material Experiment Characterization of Material
ID Subject of Study Name
NPDI-Szj4NQ Green tea (Camellia sinensis) Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects.
NPDI-K89fCg Green tea (Camellia sinensis) Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E.
NPDI-jCrpqg Green tea (Camellia sinensis) Green Tea Metabolomics
NPDI-dCfz1g Green tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450
NPDI-OeAReg Green tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation
NPDI-XM-YzA Green tea (Camellia sinensis) Green Tea Characterization of Material
NPDI-yvZDKA Green tea (Camellia sinensis) Green tea (Camellia sinensis) extract does not alter cytochrome P450 3A4 or 2D6 activity in healthy volunteers.
NPDI-7LwuzA Green tea (Camellia sinensis) Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein
NPDI-RTaSkA Green tea (Camellia sinensis) Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3
NPDI-6yhsoA Green tea (Camellia sinensis) Effects of repeated green tea catechin administration on human cytochrome P450 activity.
NPDI-S1YNJQ Green tea (Camellia sinensis) Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity.
NPDI--2FOpA Green tea (Camellia sinensis) Pharmacokinetics and Safety of Green Tea Polyphenols after Multiple-Dose Administration of Epigallocatechin Gallate and Polyphenon E in Healthy Individuals
NPDI-UC_DUA Green tea (Camellia sinensis) Blood and Urine Levels of Tea Catechins after Ingestion of Different Amounts of Green Tea by Human Volunteers
NPDI-zg6Npw Green tea (Camellia sinensis) Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities
NPDI-aujB5A Green tea (Camellia sinensis) Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes
NPDI-utgZiA Green tea (Camellia sinensis) Plasma pharmacokinetics of catechin metabolite 4'-O-Me-EGC in healthy humans