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  • Green Tea (Camellia sinensis)

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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-_MbFQg Green Tea (Camellia sinensis) Green tea (Camellia sinensis) extract does not alter cytochrome P450 3A4 or 2D6 activity in healthy volunteers. In vivo NPDI experiment In Vivo Interaction negative — No Effect (based on bioequivalence limits)
  • CYP3A4
alprazolam green tea leaf extract
NPDI-cY8J6A Green Tea (Camellia sinensis) Green tea (Camellia sinensis) extract does not alter cytochrome P450 3A4 or 2D6 activity in healthy volunteers. CYP2D6 inhibition experiment In Vivo Interaction negative — No Effect (based on bioequivalence limits)
  • CYP2D6
dextromethorphan green tea leaf extract
NPDI-qkiI-g Green Tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation In Vitro Enzyme Inhibition (Control experiment) positive — In Vitro Enzyme Inhibition
  • UGT
4-methylumbelliferone 4-methylumbelliferone glucuronide green tea leaf extract
NPDI-jljbXg Green Tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1 and 1A8 by Green Tea Leaf Extract (T21) (Ki determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A8
raloxifene raloxifene 6-glucuronide green tea leaf extract
NPDI-aqYl1g Green Tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by Green Tea Leaf Extract (T21) (Ki determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 4'-glucuronide green tea leaf extract
NPDI-y3-V_w Green Tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT
4-methylumbelliferone 4-methylumbelliferone glucuronide green tea leaf extract