CYP2D6 inhibition experiment CSV JSON

In Vivo Interaction Study

CYP2D6 inhibition experiment

No Effect (based on bioequivalence limits) was detected.

dextromethorphan 1119510

  • CYP2D6 4173631

Results

Sample Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

Fixed-sequence

Population

Healthy volunteers

Nonsmokers

CYP2D6 normal metabolizer

11

six women and five men; seven white; two Asian, two black, with a mean (+/- S.D.) age of 35 +/- 9 years

Pharmacokinetic (PK) Sampling Information

0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, 24, 36, 48, and 60 h

0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, 24, 36, 48, and 60 h

Drug or Natural Product Administration

Object Administration — dextromethorphan

Oral

suspension (Robitussin cough syrup; Wyeth-Ayerst, Princeton, NJ)

30 mg

single dose, before and after administration of green tea extract

Precipitant Administration — green tea leaf extract

Oral

Capsule of Decaffeinated Super Green Tea Extract

844 mg of green tea catechins and <4 mg of caffeine

4 capsules/day

14 days

Natural Product Characteristics

Life Extension; Fort Lauderdale, FL

No

2003