- Natural product: Green tea (Camellia sinensis)
- Associated study: Green tea (Camellia sinensis) extract does not alter cytochrome P450 3A4 or 2D6 activity in healthy volunteers.
In Vivo Interaction Study
CYP2D6 inhibition experiment
No Effect (based on bioequivalence limits) was detected.
- CYP2D6 4173631
Results
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
Fixed-sequence
Healthy volunteers
Nonsmokers
CYP2D6 normal metabolizer
11
six women and five men; seven white; two Asian, two black, with a mean (+/- S.D.) age of 35 +/- 9 years
0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, 24, 36, 48, and 60 h
0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, 24, 36, 48, and 60 h
Drug or Natural Product Administration
Oral
suspension (Robitussin cough syrup; Wyeth-Ayerst, Princeton, NJ)
30 mg
single dose, before and after administration of green tea extract
Oral
Capsule of Decaffeinated Super Green Tea Extract
844 mg of green tea catechins and <4 mg of caffeine
4 capsules/day
14 days
Life Extension; Fort Lauderdale, FL
No
2003