Inhibition of UGT1A1 and 1A8 by Green Tea Leaf Extract (T21) (Ki determination) CSV JSON

In Vitro Enzyme Inhibition Experiment

Inhibition of UGT1A1 and 1A8 by Green Tea Leaf Extract (T21) (Ki determination)

Inhibition was detected.  Cutoff used — Not provided.

raloxifene 1513103

raloxifene 6-glucuronide

  • UGT1A1 40782950
  • UGT1A8

Cell fraction Pooled human intestinal microsomes -7999663

Methanol extract of a widely avaliable commercial green tea leaf (T21, 200 mg) chemically similar to the National Institute of Standards and Technology (NIST) green tea leaf reference was used. Information regarding enzymes involved in the formation of raloxifene metabolites was obtained from Gufford et al., 2015 (Drug Metab Dispos. 2015 Sep;43(9):1353-9).

Results

Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

0.05 mg/mL

Commercially available

1410074

4 min

UDPGA

Not available

Not available

0.25-10 µM

2.5-40 µg/mL