In Vitro Enzyme Inhibition Experiment
Inhibition of UGT1A1 and 1A8 by Green Tea Leaf Extract (T21) (Ki determination)
Inhibition was detected. Cutoff used — Not provided.
- UGT1A1 40782950
Cell fraction Pooled human intestinal microsomes -7999663
Methanol extract of a widely avaliable commercial green tea leaf (T21, 200 mg) chemically similar to the National Institute of Standards and Technology (NIST) green tea leaf reference was used. Information regarding enzymes involved in the formation of raloxifene metabolites was obtained from Gufford et al., 2015 (Drug Metab Dispos. 2015 Sep;43(9):1353-9).
|Compound measured||Measurement||Value||Study sequence||Additional information||N replicates|