- Natural product: Green tea (Camellia sinensis)
- Associated study: Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation
In Vitro Enzyme Inhibition Experiment
Inhibition of UGT by (-)-Epicatechin Gallate (Screening)
Inhibition was detected. Cutoff used — 50% inhibition vs. control
Cell fraction Pooled human intestinal microsomes -7999663
The precipitant used was (-)-epicatechin gallate.
Percent inhibition was estimated from Fig. S1.
|Sample||Compound measured||Value||Measurement||Study sequence||Additional information||N replicates|
Purified green tea catechins were tested as inhibitors of UGT enzymes as described in Gufford et al., 2014 (Drug Metab Dispos. 2014 Oct;42(10):1675-83); information regarding incubation volume, time, and protein linearity were obtain therein.
Bovine serum albumin (0.05%) was added into the incubation system.