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  • Green Tea (Camellia sinensis)

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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-4i54tA Green Tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 Percent inhibition of CYP2E1 by epicatechin gallate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2E1
4-nitrophenol 4-nitrocatechol epicatechin gallate
NPDI-CPfQsA Green Tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 Percent inhibition of CYP2A6 by epicatechin gallate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2A6
coumarin 7-hydroxycoumarin epicatechin gallate
NPDI-2KGgbg Green Tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 Percent inhibition of CYP2C9 by epicatechin gallate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac epicatechin gallate
NPDI-JGDRVA Green Tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 Percent inhibition of CYP3A4 by epicatechin gallate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
midazolam 1'-hydroxymidazolam epicatechin gallate
NPDI-ArhlIA Green Tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 Percent inhibition of CYP1A2 by epicatechin gallate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A2
7-ethoxyresorufin resorufin epicatechin gallate
NPDI-X_yVFw Green Tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 Percent inhibition of CYP1A1 by epicatechin gallate In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP1A1
7-ethoxycoumarin coumarin epicatechin gallate
NPDI-AXdpJA Green Tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT by (-)-Epicatechin Gallate (IC50 determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT
4-methylumbelliferone 4-methylumbelliferone glucuronide epicatechin gallate
NPDI-Hzxkxw Green Tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epicatechin Gallate (Screening) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 6-glucuronide epicatechin gallate
NPDI-WhE0iA Green Tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epicatechin Gallate (Screening) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 4'-glucuronide epicatechin gallate
NPDI-1nd-Ow Green Tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epicatechin Gallate (Ki determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 4'-glucuronide epicatechin gallate
NPDI-WIQ_6A Green Tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epicatechin Gallate (Ki determination) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 6-glucuronide epicatechin gallate
NPDI-CWM_sQ Green Tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT by (-)-Epicatechin Gallate (Screening) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT
4-methylumbelliferone 4-methylumbelliferone glucuronide epicatechin gallate

Compound information from external resources

Resource Identifier
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