In Vitro Enzyme Inhibition Experiment
Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epicatechin Gallate (Screening)
Inhibition was detected. Cutoff used — 50% inhibition vs. control
- UGT1A1 40782950
Cell fraction Pooled human intestinal microsomes -7999663
The precipitant used was (-)-epicatechin gallate. Information regarding enzymes involved in the formation of raloxifene metabolites was obtained from Gufford et al., 2015 (Drug Metab Dispos. 2015 Sep;43(9):1353-9).
At 10 µM (-)-epicatechin gallate inhibited the formation of raloxifene 4'-glucuronide by about 65%. Percent inhibition values were estimated from Fig. S2.
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