In Vitro Enzyme Inhibition Experiment

Inhibition of UGT by (-)-Epicatechin Gallate (IC50 determination)

Inhibition was detected.  Cutoff used — Not provided

4-methylumbelliferone

epicatechin gallate

4-methylumbelliferone glucuronide

  • UGT

Cell fraction Pooled human intestinal microsomes -7999663

The precipitant used was (-)-epicatechin gallate.

Results

Sample Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

Bovine serum albumin (0.05%) was added into the incubation system.

0.2 mg/mL

Commercially available

1410074

UDPGA

Not available

Not available

100 µM

3.9-800 µM