- Natural product: Green tea (Camellia sinensis)
- Associated study: Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation
In Vitro Enzyme Inhibition Experiment
Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epicatechin Gallate (Screening)
Inhibition was detected. Cutoff used — 50% inhibition vs. control
- UGT1A1 40782950
Cell fraction Pooled human intestinal microsomes -7999663
Information regarding enzymes involved in the formation of raloxifene metabolites was obtained from Gufford et al., 2015 (Drug Metab Dispos. 2015 Sep;43(9):1353-9).
At 10 µM (-)-epicatechin gallate inhibited the formation of raloxifene 6-glucuronide by about 70%. Percent inhibition values were estimated from Fig. S2.
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