Percent inhibition of CYP3A4 by epicatechin gallate CSV JSON

In Vitro Enzyme Inhibition Experiment

Percent inhibition of CYP3A4 by epicatechin gallate

Inhibition was detected.  Cutoff used — not provided

midazolam 708298

epicatechin gallate

1'-hydroxymidazolam

  • CYP3A4 4306811

Recombinant expression system Not available
Cytochrome B5 Not available

Results

Percent inhibition at 100 µM as estimated from Fig. 3 is presented.

Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

Experiments were conducted using TA1538 cell membrane fractions expressing P450 reductase and individual CYP isoforms.

CYP: 60 pmol/mL

In-house preparation

0.5 mL

5 min

NADPH regenerating system

Not available

Not available

10 µM

0-100 µM