- Natural product: Green tea (Camellia sinensis)
- Associated study: Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein
In Vitro Transporter Inhibition Experiment
Inhibition of P-gp by (-)epigallocatecin gallate
Inhibition was detected. Cutoff used — NA
digoxin 1326303
- P-gp (ABCB1)
Cell system Caco-2 cells
Results
In the presence of (-)-epigallocatechin gallate, the B-A transport of digoxin significantly decreased from 3.2%/h to 1.6%/h (P < 0.01 to 0.001). In the presence of (-)-epigallocatechin gallate, the B-A transport was greater than the A-B transport.
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
transwell plates
7
>200 Ω
4 h
37 deg C
5 µM
1 µM
Prof. Toshiyuki Kan (Department of Synthetic Organic and Medicinal Chemistry, University of Shizuoka, Japan)