NaPDI | Compound details

Need public description.

Natural products containing this compound

Cannabis (Cannabis sativa)
Green tea (Camellia sinensis)

Enantiomer of compound
epicatechin

Compound has enantiomers
None listed

Metabolite of compounds
None listed

Compound has metabolites
None listed

ID	Subject of Study	Study Name	Name	Type	Overall Effect	Enzymes	Transporters	Object	Object Metabolite	Precipitant
NPDI-cTDX2A	Green tea (Camellia sinensis)	Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation	Inhibition of UGT by (-)-Epicatechin (Screening)	In Vitro Enzyme Inhibition	negative — In Vitro Enzyme Negligible Inhibition	UGT		4-methylumbelliferone	4-methylumbelliferone glucuronide	(-)-epicatechin
NPDI-wl1otQ	Green tea (Camellia sinensis)	Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation	Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epicatechin (Screening)	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	UGT1A1 UGT1A10 UGT1A8		raloxifene	raloxifene 4'-glucuronide	(-)-epicatechin
NPDI-VlvwrQ	Green tea (Camellia sinensis)	Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation	Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epicatechin (Screening)	In Vitro Enzyme Inhibition	positive — In Vitro Enzyme Inhibition	UGT1A1 UGT1A10 UGT1A8		raloxifene	raloxifene 6-glucuronide	(-)-epicatechin
NPDI-pD4STA	Green tea (Camellia sinensis)	Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450	Percent inhibition of CYP1A1 by (-)-epicatechin	In Vitro Enzyme Inhibition	negative — In Vitro Enzyme Negligible Inhibition	CYP1A1		7-ethoxycoumarin	coumarin	(-)-epicatechin
NPDI-PsGh1w	Green tea (Camellia sinensis)	Green Tea Characterization of Material	Green Tea Characterization of Material Experiment	Characterization of Material

ID	Subject of Study	Name
NPDI-OeAReg	Green tea (Camellia sinensis)	Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation
NPDI-dCfz1g	Green tea (Camellia sinensis)	Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450
NPDI-XM-YzA	Green tea (Camellia sinensis)	Green Tea Characterization of Material