Need public description.

  • Green Tea (Camellia sinensis)

epicatechin

None listed

None listed

None listed
ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-pD4STA Green Tea (Camellia sinensis) Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450 Percent inhibition of CYP1A1 by (-)-epicatechin In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP1A1
7-ethoxycoumarin coumarin (-)-epicatechin
NPDI-wl1otQ Green Tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epicatechin (Screening) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 4'-glucuronide (-)-epicatechin
NPDI-VlvwrQ Green Tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT1A1, 1A8, and 1A10 by (-)-Epicatechin (Screening) In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • UGT1A1
  • UGT1A10
  • UGT1A8
raloxifene raloxifene 6-glucuronide (-)-epicatechin
NPDI-cTDX2A Green Tea (Camellia sinensis) Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation Inhibition of UGT by (-)-Epicatechin (Screening) In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • UGT
4-methylumbelliferone 4-methylumbelliferone glucuronide (-)-epicatechin
NPDI-PsGh1w Green Tea (Camellia sinensis) Green Tea Characterization of Material Green Tea Characterization of Material Experiment Characterization of Material