Inhibition of UGT1A9 by Epigallocatechin Gallate CSV JSON

In Vitro Enzyme Inhibition Experiment

Inhibition of UGT1A9 by Epigallocatechin Gallate

Inhibition was detected.  Cutoff used — >20% inhibiton vs. control

mycophenolic acid

epigallocatechin gallate 19058494

mycophenolic acid 7-O-glucuronide

  • UGT1A9

Cell fraction Pooled human liver microsomes -7999662

Results

Percent inhibition was estimated from Fig. 1. Epigallocaetchin gallate at 250 mg in 53 and 5.3 L did not inhibit UGT1A9-mediated mycophenolic acid 7-O-glucuronide formation.

Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

0.16 mg/mL

Commercially available

100 µL

30 min

UDPGA

Not available

Not available

240 µM

250 mg in 0.53 L