- Natural product: Green tea (Camellia sinensis)
- Associated study: Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities
In Vitro Enzyme Inhibition Experiment
Inhibition of UGT1A9 by Epigallocatechin Gallate
Inhibition was detected. Cutoff used — >20% inhibiton vs. control
- UGT1A9
Cell fraction Pooled human liver microsomes -7999662
Results
Percent inhibition was estimated from Fig. 1. Epigallocaetchin gallate at 250 mg in 53 and 5.3 L did not inhibit UGT1A9-mediated mycophenolic acid 7-O-glucuronide formation.
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
0.16 mg/mL
Commercially available
100 µL
30 min
UDPGA
Not available
Not available
240 µM
250 mg in 0.53 L