- Natural product: Green tea (Camellia sinensis)
- Associated study: Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation
In Vitro Enzyme Inhibition Experiment
Inhibition of UGT1A1 and 1A8 by Nicardipine (Positive Control; Screening)
Inhibition was detected. Cutoff used — 50% inhibition vs. control
- UGT1A1 40782950
- UGT1A8
Cell fraction Pooled human intestinal microsomes -7999663
Results
Percent inhibition was estimated from Fig. S2.
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
Commercially available
1410074
Not available
Not available
400 µM