In Vitro Enzyme Inhibition Experiment

Inhibition of UGT1A1 and 1A8 by Nicardipine (Positive Control; Screening)

Inhibition was detected.  Cutoff used — 50% inhibition vs. control

raloxifene 1513103

nicardipine 1318137

raloxifene 6-glucuronide

  • UGT1A1 40782950
  • UGT1A8

Cell fraction Pooled human intestinal microsomes -7999663

Results

Percent inhibition was estimated from Fig. S2.

Sample Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

Commercially available

1410074

Not available

Not available

400 ┬ÁM