Inhibition of CYP2C8 by (-)-Epigallocatechin Gallate in HLM (Ki Determination) CSV JSON

In Vitro Enzyme Inhibition Experiment

Inhibition of CYP2C8 by (-)-Epigallocatechin Gallate in HLM (Ki Determination)

Inhibition was detected.  Cutoff used — Ki determination

amodiaquine

n-desethylamodiaquine

  • CYP2C8 4306333

Cell fraction Pooled human liver microsomes -7999662

Results

Sample Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

0.1 mg/mL

Commercially available

100 µL

20 min

NADPH

Not available

Not available

1.3-5.2 µM

1-218 µM