In Vitro Enzyme Inhibition Experiment
Inhibition of UGT1A1, 1A10, and 1A8 by (-)-Epigallocatechin Gallate (Screening)
Inhibition was detected. Cutoff used — 50% inhibition vs. control
- UGT1A1 40782950
Cell fraction Pooled human intestinal microsomes -7999663
Information regarding enzymes involved in the formation of raloxifene metabolites was obtained from Gufford et al., 2015.
At 10 µM (-)-epigallocatechin gallate inhibited the formation of raloxifene 4'-glucuronide by about 50%. Percent inhibition values were estimated from Fig. S2.
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