Inhibition of UGT1A1, 1A10, and 1A8 by (-)-Epigallocatechin Gallate (Screening) CSV JSON

In Vitro Enzyme Inhibition Experiment

Inhibition of UGT1A1, 1A10, and 1A8 by (-)-Epigallocatechin Gallate (Screening)

Inhibition was detected.  Cutoff used — 50% inhibition vs. control

raloxifene 1513103

raloxifene 4'-glucuronide

  • UGT1A1 40782950
  • UGT1A10
  • UGT1A8

Cell fraction Pooled human intestinal microsomes -7999663

Information regarding enzymes involved in the formation of raloxifene metabolites was obtained from Gufford et al., 2015.

Results

At 10 µM (-)-epigallocatechin gallate inhibited the formation of raloxifene 4'-glucuronide by about 50%. Percent inhibition values were estimated from Fig. S2.

Sample Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

Commercially available

1410074

Not available

Not available

100 µM

Control Experiment