- Natural product: Green tea (Camellia sinensis)
- Associated study: Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects.
In Vivo Interaction Study
Green tea interaction with nadolol
Increased systemic exposure was detected.
nadolol 1313200
- OATP1A2 (SLCO1A2)
This study suggests that green tea reduces plasma concentrations of nadolol possibly in part by inhibition of OATP1A2-mediated uptake of nadolol in the intestine.
Results
For AUC change, P < 0.001 (currently no such option in the build).
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
Fixed-sequence
Healthy volunteers
Nonsmokers
Asian
10
Ten Japanese subjects including eight males and two females; age: 20–30 years; body mass index: 18.3–23.9 kg/m 2
predose (0 h) and at 0.5, 1, 2, 3, 4, 6, 8, 24, and 48 h after nadolol administration
Drug or Natural Product Administration
Oral
not provided
30 mg
single dose
Oral
liquid
700 mL
once daily
14 days
commercial green tea beverage (Healthya; Kao, Tokyo, Japan)
2013
Pharmacodynamics (PD) & Adverse Events
As PD tests, PR, SBP, and DBP were recorded after 10 min rest in a sitting position at predose and at 0.5, 1, 2, 3, 4, 8, 24, and 48 h after nadolol administration using an automatic blood pressure monitor.
Cardiac disorders
35200000
In the water phase, nadolol lowered PR, SBP, and DBP, with maximum decreases of 20, 12, and 11%, respectively, based on arithmetic means. Coadministration of green tea tended to reduce the PD responses to nadolol in all parameters. In particular, green tea significantly suppressed the SBP-lowering effect of nadolol.