In Vivo Interaction Study
Green tea interaction with nadolol
Increased systemic exposure was detected.
- OATP1A2 (SLCO1A2)
This study suggests that green tea reduces plasma concentrations of nadolol possibly in part by inhibition of OATP1A2-mediated uptake of nadolol in the intestine.
For AUC change, P < 0.001 (currently no such option in the build).
|Compound measured||Measurement||Value||Study sequence||Additional information||N replicates|
Ten Japanese subjects including eight males and two females; age: 20–30 years; body mass index: 18.3–23.9 kg/m 2
predose (0 h) and at 0.5, 1, 2, 3, 4, 6, 8, 24, and 48 h after nadolol administration
Drug or Natural Product Administration
commercial green tea beverage (Healthya; Kao, Tokyo, Japan)
Pharmacodynamics (PD) & Adverse Events
As PD tests, PR, SBP, and DBP were recorded after 10 min rest in a sitting position at predose and at 0.5, 1, 2, 3, 4, 8, 24, and 48 h after nadolol administration using an automatic blood pressure monitor.
In the water phase, nadolol lowered PR, SBP, and DBP, with maximum decreases of 20, 12, and 11%, respectively, based on arithmetic means. Coadministration of green tea tended to reduce the PD responses to nadolol in all parameters. In particular, green tea significantly suppressed the SBP-lowering effect of nadolol.