Green tea interaction with nadolol CSV JSON

In Vivo Interaction Study

Green tea interaction with nadolol

Increased systemic exposure was detected.

nadolol 1313200

green tea leaf

  • OATP1A2 (SLCO1A2)

This study suggests that green tea reduces plasma concentrations of nadolol possibly in part by inhibition of OATP1A2-mediated uptake of nadolol in the intestine.

Results

For AUC change, P < 0.001 (currently no such option in the build).

Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

Fixed-sequence

Population

Healthy volunteers

Nonsmokers

Asian

10

Ten Japanese subjects including eight males and two females; age: 20–30 years; body mass index: 18.3–23.9 kg/m 2

Pharmacokinetic (PK) Sampling Information

predose (0 h) and at 0.5, 1, 2, 3, 4, 6, 8, 24, and 48 h after nadolol administration

Drug or Natural Product Administration

Object Administration — nadolol

Oral

not provided

30 mg

single dose

Precipitant Administration — green tea leaf

Oral

liquid

700 mL

once daily

14 days

Natural Product Characteristics

commercial green tea beverage (Healthya; Kao, Tokyo, Japan)

2013

Pharmacodynamics (PD) & Adverse Events

As PD tests, PR, SBP, and DBP were recorded after 10 min rest in a sitting position at predose and at 0.5, 1, 2, 3, 4, 8, 24, and 48 h after nadolol administration using an automatic blood pressure monitor.

Cardiac disorders 35200000

In the water phase, nadolol lowered PR, SBP, and DBP, with maximum decreases of 20, 12, and 11%, respectively, based on arithmetic means. Coadministration of green tea tended to reduce the PD responses to nadolol in all parameters. In particular, green tea significantly suppressed the SBP-lowering effect of nadolol.