Inhibition of CYP3A by (-)-Epigallocatechin Gallate in HLM (IC50 Determination) CSV JSON

In Vitro Enzyme Inhibition Experiment

Inhibition of CYP3A by (-)-Epigallocatechin Gallate in HLM (IC50 Determination)

Inhibition was detected.  Cutoff used — IC50 determination

midazolam 708298

1'-hydroxymidazolam

  • CYP3A4 4306811

Cell fraction Pooled human liver microsomes -7999662

Results

Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

0.1 mg/mL

Commercially available

100 µL

5 min

NADPH

Not available

Not available

1.7 µM

1-218 µM