Green Tea (Camellia sinensis) 19124972
Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity.
A panel of nine commonly used herbal supplements were screened for their potential to inhibit UGT1A1 activity using human liver microsomes. The result of green tea constituient epigallocatechin gallate (EGCG) was entered. Based on the in vitro findings, inhibition of UGT1A1 by EGCG is plausible, particularly in the intestine where higher extract concentrations are anticipated. Further clinical studies are warranted.
In Vitro Enzyme Inhibition Experiment
Inhibition was detected. Cutoff used — > 20% inhibition at the highest tested concentrations
- UGT1A1 40782950
Cell fraction Pooled human liver microsomes -7999662
Concentrations of herbal extracts in screening incubations represent the recommended daily intake (RDI) of each extract dissolved in 53 L, 5.3 L, and 0.53 L. For EGCG, inhibition at the represented RDI was compared with the recommended daily dose (250 mg) of EGCG. The value per dose index (VDI) value was 32.1 L, which is the highest value of all extracts tested, indicating the highest potential for inhibition.
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Precipitant concentrations were estimated from Fig. 2.