In Vitro Enzyme Inhibition Experiment
Inhibition was detected. Cutoff used — N/A
- CYP3A4 4306811
Recombinant expression system Not available
Cytochrome B5 Not available
The apparent Ki value is presented in the table.
Additional study using TA1538 cell membrane fractions of P450 reductase found that (-)-epigallocatechin gallate inhibited this enzyme competitively with an apparent Ki value of 2.5 µM.
|Sample||Compound measured||Value||Measurement||Study sequence||Additional information||N replicates|
Experiments were conducted using TA1538 cell membrane fractions expressing P450 reductase and individual CYP isoforms.
CYP: 60 pmol/mL
NADPH regenerating system