- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2)
In Vitro Transporter Inhibition Experiment
Inhibition of BCRP by Berberine
Inhibition was detected. Cutoff used — not specified
berberine 19012197
- BCRP (ABCG2)
Transfected / siRNA knock-out / injected cells HEK293 transfected cells
Results
Table 2 - significance not mentioned so assumed to be not significant
Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
---|
Experimental Conditions
7 x 10^5 cells/mL
200 μg/mL
90 min
37 deg C
5 μM
50 μM
Sigma–Aldrich, Auckland, NZ