3A4/5 Inhibition by Berberine (Plasma) CSV JSON

In Vitro Enzyme Inhibition Experiment

3A4/5 Inhibition by Berberine (Plasma)

Inhibition was detected.  Cutoff used — not specified

midazolam 708298

berberine 19012197

1'-hydroxymidazolam

  • CYP3A

Cell fraction Pooled human liver microsomes -7999662

Results

Fig 6 (Plasma) 1000 μM
Figure 4b

Sample Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

0.2 mg/ml

80 μl

10 min

NADPH regenerating system

10 μM

10 min

30, 100, 300, 600, 1000 μM