- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: The Effect of Oxidation on Berberine-Mediated CYP1 Inhibition: Oxidation Behavior and Metabolite-Mediated Inhibition
In Vitro Enzyme Inhibition Experiment
Pre-incubation w/o NADPH
Negligible Inhibition was detected. Cutoff used — not specified
- CYP1A1 4173297
Recombinant expression system E.coli
Cytochrome B5 Not available
Results
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
Commercially available
MgCl2
NADPH
P450 reductase
65.5 mM (0.5 mL)
30 min
No NADPH with precipitant