In Vitro Enzyme Inhibition Experiment

2E1 Inhibition by Berberine

Inhibition was detected.  Cutoff used — not specified

p-nitrophenol

Berberine 19012197

4-Nitrophenyl sulfate

  • CYP2E1 4173608

Cell fraction Pooled human liver microsomes -7999662

Results

Fig 1 estimate at 20 μM

Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

In-house preparation

HHM-247 and HHM-258

15 min

NADPH

10 min

No NADPH with precipitant

1 or 20 μM