- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: Repeated administration of berberine inhibits cytochromes P450 in humans
In Vivo Interaction Study
Increased systemic exposure was detected.
- CYP2D6 4173631
Table 1 - Note above is CHANGE FROM CONTROL percent while the paper reports a ratio percent of the two values
|Sample||Compound measured||Value||Measurement||Study sequence||Additional information||N replicates|
No alcohol drinking
All Chinese. "All of the subjects were free of other medications, caffeine- and alcohol-containing products as well as grapefruit prior to and during the study."
Urine samples of 0–4, 4–8, 8–12 h
Drug or Natural Product Administration
14 days administered at 8 AM with first daily dose of precipitant
300 mg three times daily (8 am, 4 pm, 11 pm)
Yunnan Baiyao Group Dali Pharmaceutical, Yunnan, China