CYP2D6 Experiment CSV JSON

In Vivo Interaction Study

CYP2D6 Experiment

Increased systemic exposure was detected.

dextromethorphan 1119510

berberine 19012197

  • CYP2D6 4173631

Results

Table 1 - Note above is CHANGE FROM CONTROL percent while the paper reports a ratio percent of the two values

Sample Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

Double-blind
Placebo-controlled
Randomized crossover
Multiple dosing

Population

Healthy volunteers
Males

No alcohol drinking
Nonsmokers

Asian

17

All Chinese. "All of the subjects were free of other medications, caffeine- and alcohol-containing products as well as grapefruit prior to and during the study."

Pharmacokinetic (PK) Sampling Information

Urine samples of 0–4, 4–8, 8–12 h

Drug or Natural Product Administration

Object Administration — dextromethorphan

Oral

Capsule

30 mg

Once Daily

14 days administered at 8 AM with first daily dose of precipitant

Precipitant Administration — berberine

Oral

Capsule

900 mg

300 mg three times daily (8 am, 4 pm, 11 pm)

14 days

Natural Product Characteristics

Yunnan Baiyao Group Dali Pharmaceutical, Yunnan, China

2011