CYP3A4 Experiment CSV JSON

In Vivo Interaction Study

CYP3A4 Experiment

Increased systemic exposure was detected.

midazolam 708298

Berberine 19012197

  • CYP3A4 4306811

Results

Table 1 - Note above is CHANGE FROM CONTROL percent while the paper reports a ratio percent of the two values

Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

Double-blind
Placebo-controlled
Randomized crossover
Multiple dosing

Population

Healthy volunteers
Males

No alcohol drinking
Nonsmokers

Asian

17

Chinese

Pharmacokinetic (PK) Sampling Information

0, 0.25,0.5,0.75,1,1.5,2,3,4,6,8,10,and12 h

Blood

Drug or Natural Product Administration

Object Administration — midazolam

Oral

Tablet

2 mg

Once daily

14 days administered at 8 AM with first daily dose of precipitant

Precipitant Administration — Berberine

Oral

Capsule

900 mg

300 mg three times daily

14 days

Natural Product Characteristics

Yunnan Baiyao Group Dali Pharmaceutical, Yunnan, China

2011