- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: Inhibition of P-Glycoprotein by HIV Protease Inhibitors Increases Intracellular Accumulation of Berberine in Murine and Human Macrophages
In Vitro Transporter Kinetics Experiment
Amprenavir P-gp Inhibition
Transport Activity was detected. Cutoff used — not specified
berberine 19012197
- P-gp (ABCB1)
Transfected / siRNA knock-out / injected cells MDCK transfected cells
Results
Figure 5b - reported value above is for 25 μM of Amprenavir vs control and is significant p< 0.05
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
Amprenavir concentration tested: 5, 15, and 25 μM
5
4 h
37 deg C
5 μM