CYP1A2 Experiment CSV JSON

In Vivo Interaction Study

CYP1A2 Experiment

No Effect (based on bioequivalence limits) was detected.

caffeine 1134439

berberine 19012197

  • CYP1A2 4312402

Results

Cmax and AUC -> converted from ยตg (in paper) to ng for repo (Table 1)

Note above is CHANGE FROM CONTROL percent while the paper reports a ratio percent of the two values

Sample Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

Double-blind
Placebo-controlled
Randomized crossover
Multiple dosing

Population

Healthy volunteers
Males

No alcohol drinking
Nonsmokers

Asian

17

Chinese

Pharmacokinetic (PK) Sampling Information

0, 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 10, and 12 h

Blood

Drug or Natural Product Administration

Object Administration — caffeine

Oral

Drink

93 mg

once daily

14 days administered at 8 AM with first daily dose of precipitant

Precipitant Administration — berberine

Oral

capsule

900 mg

Three times daily

14 days

Natural Product Characteristics

Not specified

"Standard cup of coffee"