- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: Repeated administration of berberine inhibits cytochromes P450 in humans
In Vivo Interaction Study
CYP1A2 Experiment
No Effect (based on bioequivalence limits) was detected.
- CYP1A2 4312402
Results
Cmax and AUC -> converted from ยตg (in paper) to ng for repo (Table 1)
Note above is CHANGE FROM CONTROL percent while the paper reports a ratio percent of the two values
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
Double-blind
Placebo-controlled
Randomized crossover
Multiple dosing
Healthy volunteers
Males
No alcohol drinking
Nonsmokers
Asian
17
Chinese
0, 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 10, and 12 h
Blood
Drug or Natural Product Administration
Oral
Drink
93 mg
once daily
14 days administered at 8 AM with first daily dose of precipitant
Oral
capsule
900 mg
Three times daily
14 days
Not specified
"Standard cup of coffee"