- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: Repeated administration of berberine inhibits cytochromes P450 in humans
In Vivo Interaction Study
No Effect (based on bioequivalence limits) was detected.
- CYP1A2 4312402
Cmax and AUC -> converted from µg (in paper) to ng for repo (Table 1)
Note above is CHANGE FROM CONTROL percent while the paper reports a ratio percent of the two values
|Sample||Compound measured||Value||Measurement||Study sequence||Additional information||N replicates|
No alcohol drinking
0, 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 10, and 12 h
Drug or Natural Product Administration
14 days administered at 8 AM with first daily dose of precipitant
Three times daily
"Standard cup of coffee"