2D6 Inhibition by Berberine CSV JSON

In Vitro Enzyme Inhibition Experiment

2D6 Inhibition by Berberine

Inhibition was detected.  Cutoff used — Not Specified

bufuralol

berberine 19012197

1'-hydroxybufuralol

  • CYP2D6 4173631

Cell fraction Pooled human liver microsomes -7999662

Results

Estimate at 500 μM Fig 4b

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

1 mg/mL

Commercially available

30 min

NADPH

25 μ􏱂M

No NADPH with precipitant

10, 100, and 500 μ􏱂M