- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components
In Vitro Enzyme Inhibition Experiment
2D6 Inhibition by Berberine
Inhibition was detected. Cutoff used — Not Specified
- CYP2D6 4173631
Cell fraction Pooled human liver microsomes -7999662
Results
Estimate at 500 μM Fig 4b
Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
---|
Experimental Conditions
1 mg/mL
Commercially available
30 min
NADPH
25 μM
No NADPH with precipitant
10, 100, and 500 μM