3A4 Inhibition by (+) Hydrastine CSV JSON

In Vitro Enzyme Inhibition Experiment

3A4 Inhibition by (+) Hydrastine

Inhibition was detected.  Cutoff used — not specified

testosterone

hydrastine

6beta-hydroxytestosterone

  • CYP3A4 4306811

Cell fraction Pooled human liver microsomes -7999662

Results

Fig 4a at 1000 μM

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

0.2 mg/mL

Commercially available

15 min

NADPH

200 μ􏱂M

No NADPH with precipitant

10, 100, and 1000 μ􏱂M