- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: Human Cytochrome P450 Inhibition and Metabolic-Intermediate Complex Formation By Goldenseal Extract and Its Methylenedioxyphenyl Components
In Vitro Enzyme Inhibition Experiment
3A4 Inhibition by GS Extract
Inhibition was detected. Cutoff used — not specified
- CYP3A4 4306811
Cell fraction Pooled human liver microsomes -7999662
Results
Fig 2 at 1%
Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
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Experimental Conditions
0.2 mg/mL
Commercially available
15 min
NADPH
200 μM
No NADPH with precipitant