- Natural product: Kratom (Mitragyna speciosa)
- Associated study: Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids
In Vitro Enzyme Inhibition Experiment
Control Positive Inhibition for CYP3A4/5
Inhibition was detected. Cutoff used —
IC50 = 45 μM
- CYP3A4 4306811
- CYP3A5
Cell fraction Pooled human liver microsomes -7999662
Results
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
Table S2
0.1 mg/ml
200 µL
5 min
NADPH
100 µM