- Natural product: Kratom (Mitragyna speciosa)
- Associated study: Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom)
In Vitro Enzyme Screen Experiment
Mitragynine metabolism and metabolite formation
Metabolism was detected.
- CYP3A4 4306811
Cell fraction Pooled human liver microsomes -7999662
% remaining was inferred from panel A of Fig 5 where the total contribution of each enzyme to MTG metabolism is shown. Note that other reactions besides 7-OH-MTG were also included in the total contribution of metabolism calculation.
|Sample||Compound measured||Value||Measurement||Study sequence||Additional information||N replicates|