In Vitro Enzyme Inhibition Experiment

Inhibition of CYP2C8 by Licochalcone A

Inhibition was detected.  Cutoff used —

50 % inhibition

amodiaquine

licochalcone a

n-desethylamodiaquine

  • CYP2C8 4306333

Cell fraction Pooled human liver microsomes -7999662

Results

Results come from both Table 1 and Figure 3

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

0.2 mg/mL

10 min

NADPH

1 µM

3.38 μg/mL