- Natural product: Licorice (Glycyrrhiza glabra)
- Associated study: Cytochrome P450 inhibition by licorice species Glycyrrhiza glabra L. and fourteen licorice constituents
In Vitro Enzyme Inhibition Experiment
Inhibition of CYP2C8 by G. glabra Licorice extract
Inhibition was detected. Cutoff used —
> 100 µg/mL
- CYP2C8 4306333
Cell fraction Pooled human liver microsomes -7999662
Results
| Sample | Compound measured | Value | Measurement | Study sequence | Additional information | N replicates |
|---|
Experimental Conditions
0.2 mg/mL
10 min
NADPH
1 µM
11 concentrations from 0.005–250 μg/mL