Inhibition of CYP2C8 by Licoricidin CSV JSON

In Vitro Enzyme Inhibition Experiment

Inhibition of CYP2C8 by Licoricidin

Inhibition was detected.  Cutoff used —

50 % inhibition

amodiaquine

licoricidin

n-desethylamodiaquine

  • CYP2C8 4306333

Cell fraction Pooled human liver microsomes -7999662

Results

Figure 3

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

0.2 mg/mL

10 min

NADPH

1 µM

4.25 μg/mL