Inhibition of CYP2C9 by Licoricidin CSV JSON

In Vitro Enzyme Inhibition Experiment

Inhibition of CYP2C9 by Licoricidin

Inhibition was detected.  Cutoff used —

50 % inhibition

tolbutamide

licoricidin

hydroxymethyltolbutamide

  • CYP2C9 4309227

Cell fraction Pooled human liver microsomes -7999662

Results

Figure 3

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

0.2 mg/mL

10 min

NADPH

100 µM

4.25 μg/mL