In Vitro Enzyme Inhibition Experiment

2D6 Inhibition by Hydrastine

Negligible Inhibition was detected.  Cutoff used — not specified

dextromethorphan 1119510


dextrorphan 4349487

  • CYP2D6 4173631

Cell fraction Pooled human liver microsomes -7999662


Fig 1 estimate at 20 μM

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

In-house preparation

HHM-247 and HHM-258

15 min


10 min

No NADPH with precipitant

1 or 20 μM