3A4/5 Inhibition by Hydrastine (PB) CSV JSON

In Vitro Enzyme Inhibition Experiment

3A4/5 Inhibition by Hydrastine (PB)

Inhibition was detected.  Cutoff used — not specified

midazolam 708298

hydrastine

1'-hydroxymidazolam

  • CYP3A

Cell fraction Pooled human liver microsomes -7999662

Results

Inhibition from Fig 6 (300 μM)
Fig 4a. (in parentheses)

Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

0.2 mg/ml

80 μl

10 min

NADPH regenerating system

10 μM

10 min

3, 10, 30, 100, 300 μM