- Natural product: Goldenseal (Hydrastis canadensis)
- Associated study: An in vitro Evaluation of Cytochrome P450 Inhibition and P-Glycoprotein Interaction with Goldenseal, Ginkgo biloba, Grape Seed, Milk Thistle, and Ginseng Extracts and Their Constituents
In Vitro Enzyme Inhibition Experiment
1A2 Inhibition by Hydrastine
Inhibition was detected. Cutoff used — not specified
Results
Fig 1 estimate at 20 μM
Sample | Compound measured | Value | Measurement | Additional information | N replicates |
---|---|---|---|---|---|
acetaminophen | 22 ± 10% | % Inhibition Mean ± SD | P-value: P < 0.05 | 3 |
Experimental Conditions
In-house preparation
HHM-247 and HHM-258
15 min
NADPH
10 min
No NADPH with precipitant
1 or 20 μM