In Vitro Enzyme Inhibition Experiment

1A2 Inhibition by Hydrastine

Inhibition was detected.  Cutoff used — not specified

acetanilide

hydrastine

acetaminophen 1125315

Cell fraction Pooled human liver microsomes -7999662

Results

Fig 1 estimate at 20 μM

Sample Compound measured Value Measurement Study sequence Additional information N replicates
acetaminophen22 ± 10%% Inhibition
Mean ± SD
Test
P-value:
P < 0.05
3

Experimental Conditions

In-house preparation

HHM-247 and HHM-258

15 min

NADPH

10 min

No NADPH with precipitant

1 or 20 μM