In Vitro Enzyme Inhibition Experiment

3A4 Inhibition by Ethanolic GS Extract (MDZ)

Inhibition was detected.  Cutoff used — not specified

midazolam 708298

1'-hydroxymidazolam

  • CYP3A4 4306811

Cell fraction Pooled human liver microsomes -7999662

Results

Fig 1 Estimate at 20 μM

Sample Compound measured Measurement Value Study sequence Additional information N replicates

Experimental Conditions

In-house preparation

HHM-247 and HHM-258

15 min

NADPH

10 min

No NADPH with precipitant

1 or 20 μM