Inhibition of Paynantheine for CYP3A4/5 CSV JSON

In Vitro Enzyme Inhibition Experiment

Inhibition of Paynantheine for CYP3A4/5

Inhibition was detected.  Cutoff used —

IC50 = 45 μM

midazolam 708298

paynantheine

1'-hydroxymidazolam

  • CYP3A4 4306811
  • CYP3A5

Cell fraction Pooled human liver microsomes -7999662

Results

% result estimated from Figure S5 at around 100 µM

Sample Compound measured Value Measurement Study sequence Additional information N replicates

Experimental Conditions

0.1 mg/ml

200 µL

10 min

NADPH

4 µM

0 - 100 µM

Control Experiment