methanolic extract of kratom

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Compound information managed by NaPDI

  • Kratom (Mitragyna speciosa)

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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-7-Gg-g Kratom (Mitragyna speciosa) Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations Screening of kratom extracts as inhibitors of CYP3A activity in HLM In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A
midazolam 1'-hydroxymidazolam methanolic extract of kratom
NPDI-Df2Xyw Kratom (Mitragyna speciosa) Evaluation of selected Malaysian medicinal plants on phase I drug metabolizing enzymes, CYP2C9, CYP2D6 and CYP3A4 activities in vitro Negligible inhibition of CYP3A4 by M. speciosa methanolic extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
luciferin 6’benzyl ether (luciferin-be) luciferin methanolic extract of kratom
NPDI-gWxQZg Kratom (Mitragyna speciosa) Evaluation of selected Malaysian medicinal plants on phase I drug metabolizing enzymes, CYP2C9, CYP2D6 and CYP3A4 activities in vitro Inhibition of CYP2D6 by M. speciosa methanolic extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
ethylene glycol ester of luciferin 6’methyl ether (luciferin me-ege) luciferin methanolic extract of kratom
NPDI-jkwBEg Kratom (Mitragyna speciosa) Evaluation of selected Malaysian medicinal plants on phase I drug metabolizing enzymes, CYP2C9, CYP2D6 and CYP3A4 activities in vitro Inhibition of CYP2C9 by M. speciosa methanolic extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP2C9
6’deoxyluciferin (luciferin h) luciferin methanolic extract of kratom
NPDI-71pBaQ Kratom (Mitragyna speciosa) Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations Screening of kratom extracts as inhibitors of CYP2C9 activity in HLM In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2C9
diclofenac 4'-hydroxydiclofenac methanolic extract of kratom
NPDI-o6FZsw Kratom (Mitragyna speciosa) Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations Screening of kratom extracts as inhibitors of CYP2D6 activity in HLM In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
dextromethorphan dextrorphan methanolic extract of kratom