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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-ypADxQ Kratom (Mitragyna speciosa) Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities No inhibition of CYP3A4 by mitragynine In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
luciferin 6’benzyl ether (luciferin-be) luciferin mitragynine
NPDI-M8nR1A Kratom (Mitragyna speciosa) Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities Enzyme kinetics of CYP3A4 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • CYP3A4
luciferin 6’benzyl ether (luciferin-be) luciferin
NPDI-d-iKog Kratom (Mitragyna speciosa) Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities POS. CONTROL: Inhibition of CYP3A4 by ketoconazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
luciferin 6’benzyl ether (luciferin-be) luciferin ketoconazole
NPDI-Df2Xyw Kratom (Mitragyna speciosa) Evaluation of selected Malaysian medicinal plants on phase I drug metabolizing enzymes, CYP2C9, CYP2D6 and CYP3A4 activities in vitro Negligible inhibition of CYP3A4 by M. speciosa methanolic extract In Vitro Enzyme Inhibition negative — In Vitro Enzyme Negligible Inhibition
  • CYP3A4
luciferin 6’benzyl ether (luciferin-be) luciferin methanolic extract of kratom
NPDI-79TG7g Kratom (Mitragyna speciosa) Evaluation of selected Malaysian medicinal plants on phase I drug metabolizing enzymes, CYP2C9, CYP2D6 and CYP3A4 activities in vitro POS. CONTROL: Inhibition of CYP3A4 by ketoconazole In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP3A4
luciferin 6’benzyl ether (luciferin-be) luciferin ketoconazole