In Vitro Enzyme Inhibition Experiment
POS. CONTROL: Inhibition of CYP3A4 by ketoconazole
Inhibition was detected. Cutoff used — Not specified.
- CYP3A4 4306811
Recombinant expression system Baculovirus-insect cells
Cytochrome B5 Not available
|Sample||Compound measured||Value||Measurement||Study sequence||Additional information||N replicates|
Positive controls sulfaphenazole, quinidine, and ketoconazole were purchased from Sigma Chemicals (St. Louis, USA). This assay was carried out using the P450-Glo™ Screening Systems from Promega, USA.
The minus-P450 wells (using luciferin-free water) were negative controls.
NADPH regenerating system