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ID Subject of Study Study Name Name Type Overall Effect Enzymes Transporters Object Object Metabolite Precipitant
NPDI-FnVAqw Kratom (Mitragyna speciosa) Evaluation of selected Malaysian medicinal plants on phase I drug metabolizing enzymes, CYP2C9, CYP2D6 and CYP3A4 activities in vitro POS. CONTROL: Inhibition of CYP2D6 by quinidine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
ethylene glycol ester of luciferin 6’methyl ether (luciferin me-ege) luciferin quinidine
NPDI-_PhwAA Kratom (Mitragyna speciosa) Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities Inhibition of CYP2D6 by mitragynine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
ethylene glycol ester of luciferin 6’methyl ether (luciferin me-ege) luciferin mitragynine
NPDI-o-4ZoA Kratom (Mitragyna speciosa) Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities Enzyme kinetics of CYP2D6 In Vitro Enzyme Kinetics positive — In Vitro Detectable Kinetic Metabolism
  • CYP2D6
ethylene glycol ester of luciferin 6’methyl ether (luciferin me-ege) luciferin
NPDI-gWxQZg Kratom (Mitragyna speciosa) Evaluation of selected Malaysian medicinal plants on phase I drug metabolizing enzymes, CYP2C9, CYP2D6 and CYP3A4 activities in vitro Inhibition of CYP2D6 by M. speciosa methanolic extract In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
ethylene glycol ester of luciferin 6’methyl ether (luciferin me-ege) luciferin methanolic extract of kratom
NPDI-d0noGQ Kratom (Mitragyna speciosa) Inhibitory effect of mitragynine on human cytochrome P450 enzyme activities POS. CONTROL: Inhibition of CYP2D6 by quinidine In Vitro Enzyme Inhibition positive — In Vitro Enzyme Inhibition
  • CYP2D6
ethylene glycol ester of luciferin 6’methyl ether (luciferin me-ege) luciferin quinidine